Amina CHENTOUF

Abstract
Purpose: The goal of this retrospective study is to identify early predictors of in- tractable epilepsy.
Methods: This case-control study conducted from January 2007 to December 2012 included 106 patients with drug-resistant epilepsy and 212 controls with well-con- trolled epilepsy.Univariate and multivariate analysis of predictive factors of refractoriness were performed using logistic regression. Results: in the final model, four factors significantly associated with intraitable epilepsy were identifier: aetiology (p=0.001), high initial seizure fréquence (p<0.0001), status epilepticus (p=0.002) and initial myoclonic seizures (p<0.0001). Conclusion: Our findings suggest that the Risk of developing drug résistant epilepsy could be predicted at an early stage of the disease by some clinicat features. This could help the cliniciens to make the best therapy décisions and improve patient's Quality of Life.