Plateforme Télé-Enseignement de l'Université Oran 1 Ahmed Ben Bella

يتوزّع الكتاب على ثمانية فصول حاول من خلالها المؤلّف توضيح أهمية النقل و الترجمة في الحضارة الإسلامية

Abstract

Introduction: Pulmonary hypertension (PH) in children is a serious disease. There is few data describing pediatric PH. PH, long considered to be outstanding, is poorly known in Algeria where the diagnostic means and the supply of care are significantly limited. Our work item on the situation in the West Algerian and is part of a strategy to improve the diagnosis and support.

Objectives: The objective was to describe the clinical features and management of PH in children, as well as its effects on the quality of life and its consequences, excluding patients with persistent pulmonary hypertension of the newborn. Methods: This prospective non interventional study included children with PH who were prospectively followed for two years in in a pediatric center in Oran. The WHO functional classification, the 6-minute walk distance, were evaluated.

Results: Sixty children with a mean age of 6,4 ± 4,6 years in 12 cities in the West Algerian were included from January 2020 to January 2022. The diagnosis is late (3 years on average). The prevalence of PH was estimated at 2,2 cases per 100.000 children in the wilaya of Oran. The patients had the following types of PH: associated with congenital heart disease (73%), idiopathic (6%), associated with an HIV (3%) or associated with diffuse interstitial lung disease (3%). Although there may be misleading clinical signs, it is therefore imperative that PH is recognised and that its severity is assessed. Echocardiography is the essential examination which is most often used to assess PAH and its effects. During follow-up there was an increase in the number of drugs prescribed specifically for pulmonary arterial hypertension (44% patients versus 22% at inclusion). The clinical status, 6-minute walk test and quality of life of the majority of patients remained stable. The survival at one and at two years was estimated at 95% and 93,3% respectively (95% confidence interval).

Conclusion: The majority of cases of PH in children are secondary to congenital heart disease or idiopathic. The prognosis depends largely on its etiology. The use of specific treatments for PAH may contribute to the stability of the disease and to better survival. Progress in understanding the pathophysiology will open the way to new therapeutic choices.

Keywords: Pediatric Pulmonary Hypertension; Congenital Heart Defect; Epidemiology; Pulmonary Vasodilators

Abstract

Introduction: Kasabach-Merritt syndrome is a rare form of vascular tumor that are often misdiagnosed, which is complicated by intra-tumor coagulopathy and requiring urgent management.

Objective: This review highlights the clinical presentation, histopathology, management, and treatment of Kasabach-Merritt syndrome. A clinical case compiled in the pediatric department of the university Hospital Center of Oran Algeria, is described to illustrate the presentation and our management of a patient with Kasabach-Merritt syndrome.

Observation: A female infant was admitted, on the thirtieth day of life, for a purplish red swelling of the left hemiface. He had hemolytic anemia, profound thrombocytopenia and consumptive coagulopathy. It was successfully managed with a combination of high dose of oral corticosteroids and vincristine.

Conclusion: Vincristine and oral corticosteroids were useful for our patient and may be considered an option for first-line therapy of Kasabach-Merritt syndrome. The absence of a codified therapeutic protocol makes the management of this tumor a real challenge.

Keywords: Kasabach-Merritt Syndrome; Thrombocytopenia; Hemangiomas; Coagulopathy; Vascular Tumor; Kaposiform Hemangioendothelioma

Le diabète de l'enfant est une maladie chronique au retentissement lourd, à la fois pour l'enfant, sa famille et les professionnels de santé. l'exposition importante à l'hyperglycémie pendant une période prolongée de l'enfance et de l'adolescence peut être responsable de l'apparition des complications chroniques chez le jeune adulte. L'augmentation du risque cardio-vasculaire chez les enfants diabétiques de type 1, est unanimement reconnu. Les lésions athéromateuses, peuvent se développer précocement chez les enfants diabétiques et l'athérosclérose est beaucoup plus fréquente et sévère chez le diabétique que dans la population générale. Face à ce constat, il est impératif de penser précocement à la macroangiopathie, d'obtenir un bon contrôle glycémique et des facteurs de risque cardiovasculaire connus et de mettre en place un suivi cardiovasculaire précoce. Ces complications ne sont pas inéluctables et il est donc possible d'intervenir de manière efficace pour les prévenir, mais malgré le fait que ces patients sont à haut risque de maladie cardiovasculaire, peu de recommandations spécifiques au diabète concernant le dépistage sont disponibles notamment chez l'enfant.

Polycopie de cours du premier trimestre, on y trouve une partie sur la structure de la matière (l'atomistique), et la seconde sur la liaison chimique avec les trois modèles, Lewis, VSEPR et LCAO.

Gallbladder cancer is the fifth most frequent women cancer in Algeria. Squamous-cell and adenosquamous carcinomas are the rarest histological type of this cancer and represent less than 7%. Malformation of the bile ducts such as a choledochal cyst or a biliopancreatic maljunction are risk factors for this cancer. This manuscript reports a rare case of an 82-year-old woman operated on for an adenosquamous carcinoma of the gallbladder associated with a bile duct cyst and a biliopancreatic junction abnormality. Aggressive surgery was performed combined with adjuvant oral chemotherapy. Twenty-nine months of recurrence-free survival was achieved by this patient suffering from this aggressive and rare form of gallbladder cancer.

https://doi.org/10.1002/aid2.13327

تتضمن هاته المطبوعة محاضرات علمية موجهة لطلبة قسم أصول الدين بكلية العلوم الإنسانية والعلوم الإسلامية تتضمن محاضرات في التفسير الموضوعي إذ أنها بينت حقيقة هذا المنهج و تاريخيته و كذا صلته بباقي المناهج التفسيرية و قدمت نماذج تطبيقية له 

فيمايلي أمالي لطلبة ماستر تفسير بقسم أصول الدين وهي متعلقة بعلم المقاصد القرآنية ، فيها بيان لماهية العلم  وضبط لأنواعه و مسالك الكشف عنها